New research suggests that treating infected teeth with root canals can improve blood sugar control, cholesterol levels, and reduce inflammation – all key factors in preventing heart disease and diabetes. The findings, published in the Journal of Translational Medicine, indicate that oral health is far more connected to systemic well-being than previously understood.
The Mouth-Body Connection
The human mouth harbors a complex ecosystem of bacteria. While some are harmless or beneficial, others can cause tooth decay, gum disease, and infections. When left untreated, these infections can trigger low-grade inflammation throughout the body, disrupting metabolic processes and potentially raising the risk of chronic illnesses.
The study focused on apical periodontitis, inflammation around the root of an infected tooth. Researchers hypothesized that eliminating this infection through root canal treatment could reverse some of the associated metabolic damage.
Study Design and Key Findings
Researchers at a dental hospital in England tracked 65 adults before and after they underwent root canal procedures. Blood samples were analyzed over two years using advanced NMR spectroscopy to assess over 40 biomarkers related to cardiometabolic risk. The study employed a “self-controlled” design, meaning each participant served as their own control group, minimizing the influence of individual differences.
Results showed significant improvements in key health indicators following successful root canal treatment:
- Blood Sugar Control: Participants exhibited lower glucose levels two years post-treatment, indicating a reduced diabetes risk.
- Cholesterol Levels: Short-term improvements were observed in cholesterol and fatty acid profiles, benefiting heart health.
- Inflammation Reduction: Markers of inflammation linked to chronic diseases decreased over time.
The lead author, Dr. Sadia Niazi of King’s College London, emphasizes that this is evidence of a body-wide effect. “Oral bacteria from infected teeth can disrupt metabolism, showing how oral health impacts the whole body,” she stated.
Why This Matters
These findings reinforce the growing recognition that systemic inflammation plays a central role in the development of metabolic and cardiovascular diseases. Poor oral health is no longer simply a cosmetic concern; it is a modifiable risk factor for serious chronic conditions.
Experts agree. Dr. Eleanor Levin of Stanford Medicine, not involved in the study, notes that reducing inflammation through interventions like root canal treatment can improve metabolic health. “The root canal reduces the inflammation by removing the site of the dental infection,” she says.
Maintaining Oral and Metabolic Health
To minimize risk, dental professionals recommend the following:
- Brush twice daily with fluoride toothpaste.
- Floss at least once a day.
- Schedule regular dental cleanings and checkups.
- Limit sugary foods and drinks.
- Avoid smoking.
- Engage in daily physical activity.
In conclusion, the evidence is mounting that oral health and systemic health are inextricably linked. Timely dental care, including root canal treatment when necessary, is not just about preserving teeth – it’s about protecting long-term metabolic and cardiovascular well-being.

































